The biology of the mesothelium during peritoneal dialysis.

مقایسه سلول‌های مزانشیمی مغز استخوان و سلول‌های مزوتلیومی مایع سروزی ازنظر میزان بیان مولکول‌های کمپلکس سازگاری نسجی اصلی (MHC)

Abstract Background: Mesothelium is composed of a single layer of mesothelial cells attached to a thin basement membrane supported by subserosal connective tissue it plays an important role in homeostasis, wound healing, fluid transport and inflammation. The introduction of peritoneal dialysis (PD) as a modality of renal replacement therapy has provoked much interest in the biology of perito...

dialysate contains unphysiological levels of glucose as the osmotic agent. This constant exposure to hyperosmolar and low pH dialysis solution, with high glucose concentration causes additional injury to the peritoneal mesothelium, already damaged by the uremic internal millieu

Investigating peritoneal membrane alterations caused by peritoneal dialysis fluid during peritoneal dialysis in humans is still intriguing. That is why the study was aimed to provide rabbit peritoneal tissue samples suitable for histological analyses using a modified nonuremic infusion model of peritoneal dialysis on rabbit. A double-lumen central venous catheter, surgically placed in the perit...

Peritoneal Adipocytes and Their Role in Inflammation during Peritoneal Dialysis

Adipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated inflammation plays a significant contributory role in the development of chronic inflammation in patients undergoing maintenance PD. However, the molecular and cellular mechanisms of this link remain uncertain. Adipose tissue synthesizes diffe...

Angiogenic Activity of the Peritoneal Mesothelium: Implications for Peritoneal Dialysis

Effect of glucose on intercellular junctions of cultured human peritoneal mesothelial cells.

During continuous ambulatory peritoneal dialysis, the peritoneum is directly and continuously exposed to unphysiologic peritoneal dialysis fluid; the resulting mesothelial damage has been suggested to cause loss of ultrafiltration and dialysis efficacy. The present study investigated the effect of a high glucose concentration on cultured human peritoneal mesothelial cells to clarify the cause o...